Special Issue: Amine oxidases: structures, mechanisms and therapeutic targets

Special issue: potential therapeutic targets involving 5-HT6 and 5-HT7 receptors.

Serotonin or 5-hydroxytryptamine (5-HT) has a long history in scientific investigation, ranging from gastrointestinal, feeding, and cardiovascular functions to migraine and emotional and pain problems. 5-HT has multiple receptors, and particularly, the 5-HT6 and 5-HT7 receptors have been shown to be involved in functions and dysfunctions of the central nervous system and have become targets in ...

NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.

PURPOSE Cancer cells show higher levels of reactive oxygen species (ROS) than normal cells and increasing intracellular ROS levels are becoming a recognized strategy against tumor cells. Thus, diminishing ROS levels could be also detrimental to cancer cells. We surmise that avoiding ROS generation would be a better option than quenching ROS with antioxidants. Chronic myelogenous leukemia (CML) ...

Special Issue

Substrate specificity of amine oxidases.

DuBois, K. P., Albaum, H. G. & Potter, V. R. (1943). J. biol. Chem. 147, 699. Green, H. N. (1943). Lancet, 2, 147. Green, H. N. & Stoner, H. B. (1944). Brit. J. exp. Path. 25, 150. Kal¢kar, H. M. (1943). J. biol. Chem. 148, 127. Kolthoff, I. M. (1932). Saure-Ba8en Indicatoren. Berlin: Springer. Krebs, H. A. & Henseleit, K. (1932). Ho.ppe-Seyl. Z. 210, 33.' Lyubimova, M. N. & Pevsner, D. (1941)....

NADPH oxidases as therapeutic targets in chronic myeloid leukemia

NADPH oxidases as therapeutic targets in chronic myeloid leukemia Authors: Beatriz Sánchez-Sánchez, Sara Gutiérrez-Herrero, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Marta Romo-González, Marcial Llanillo, Atanasio Pandiella, Carmen Guerrero, Jesús F. San Miguel , Fermín Sánchez-Guijo, Consuelo del Cañizo, and Angel Hernández-Hernández Affiliations: Department of Biochemistry and Molecular ...